Search on: COMPLEMENT PATHWAY, MANNOSE-BINDING LECTIN 
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Descriptor English:   Complement Pathway, Mannose-Binding Lectin 
Descriptor Spanish:   Lectina de Unión a Manosa de la Vía del Complemento 
Descriptor Portuguese:   Lectina de Ligação a Manose da Via do Complemento 
Synonyms English:   Lectin-Complement Pathway
Mannan-Binding Lectin Complement Pathway
Mannose-Binding Lectin Complement Pathway  
Tree Number:   G12.425.255.849
Definition English:   Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX. 
See Related English:   Mannose-Binding Lectin
 
History Note English:   2003 
Allowable Qualifiers English:  
DE drug effects ES ethics
GE genetics IM immunology
PH physiology RE radiation effects
Record Number:   37640 
Unique Identifier:   D037582 

Occurrence in VHL: 		 

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